Website: Ottawa Hospital Research Institute
Department: As of Oct 1/12, Bernard Thébaud will be moving to the Ottawa Hospital Research Institute and Children’s Hospital of Eastern Ontario.
Our lab is focused on understanding the mechanisms of lung development, injury and repair in order to develop new treatments for incurable lung diseases. We have an ambitious research program with the ability to study clinically relevant research questions from molecule to man. All animal models of human lung disease are available in our lab and we correlate structural changes with function to assess the clinical pertinence of the experimental therapies tested in our lab. Over the past 6 years, our major research contributions included (i) the discovery of the role of angiogenesis for normal lung development and repair, (ii) the demonstration of the therapeutic potential of stem cells in experimental bronchopulmonary dysplasia (BPD), asthma, COPD and pulmonary hypertension. Over the next 5 years, the major goal will be to translate cell-based therapies into the clinic.
Recent Stem Cell Publications:
Waszak P, Alphonse R, Vadivel A, Ionescu L, Eaton F, Thébaud B. Preconditioning Enhances the Paracrine Effect of Mesenchymal Stem Cells in Preventing Oxygen-Induced Neonatal Lung Injury in Rats. Stem Cells Dev. 2012 Jun 7. [Epubahead of print] PMID: 22533467.
Waszak P, Alphonse R, Vadivel A, Ionescu L, Eaton F, Thébaud B. Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma. Am J Respir Cell Mol Biol. 2012 Feb;46(2):207-16.
vanHaaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, Bouchentouf M, Rey-Parra GJ, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thébaud B. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J RespirCrit Care Med. 2009 Dec 1;180(11):1131-42.